Bioelectronic medicine is driving the need for neuromorphic microcircuits that integrate raw nervous stimuli and respond identically to biological neurons. However, designing such circuits remains a challenge. Here we estimate the parameters of highly nonlinear conductance models and derive the ab initio equations of intracellular currents and membrane voltages embodied in analog solid-state electronics. By configuring individual ion channels of solid-state neurons with parameters estimated from large-scale assimilation of electrophysiological recordings, we successfully transfer the complete dynamics of hippocampal and respiratory neurons in silico. The solid-state neurons are found to respond nearly identically to biological neurons under stimulation by a wide range of current injection protocols. The optimization of nonlinear models demonstrates a powerful method for programming analog electronic circuits. This approach offers a route for repairing diseased biocircuits and emulating their function with biomedical implants that can adapt to biofeedback. Continua su https://www.nature.com/articles/s41467-019-13177-3 Ne scrive anche Enrica Battifoglia per Ansa: http://www.ansa.it/canale_scienza_tecnica/notizie/biotech/2019/12/04/-primo-... Certamente un ambito di ricerca enormemente interessante dal punto di vista medico, che magari fra qualche decennio porterà ad una forte mitigazione dei sintomi delle malattie neurodegenerative. Eppure apre anche a scenari inquietanti. Giacomo